Ion Ghiviriga
Director of the Center for NMR Spectroscopy
Research Focus
Nuclear Magnetic Resonance (NMR) is the most powerful method for elucidation of the structure of organic compounds, and most of our research involves collaborations in which we find out what compounds have been obtained in a particular reaction, or isolated from a natural source. We use dynamic NMR and molecular modeling to study the conformational equilibria of small molecules. Ion’s independent research focuses on quantitative NMR with applications in titering organometal reagents or measuring the solubility of drug candidates in different solvents or formulations.
Education and Training
1993–1996: Postdoc, University of Florida (lab of Alan R. Katritzky)
1989–1993: Ph.D. Chemistry, Polytechnic University of Bucharest (with Prof. Alexandru T. Balaban)
Selected Publications
Ghiviriga, I.; Nuclear Magnetic Resonance Method for Measuring Water Solubility of Organic Compounds. Anal. Chem. 2023, 95, 2706–2712. DOI: 10.1021/acs.analchem.2c03277.
Jakhar, V. K.; Johnson, E. C.; Kavuturu, A.; Heller, J. K.; Veige, A. S.; Ghiviriga, I. Precise NMR Method for Titering Organometal Reagents (vol 23, pg 4945, 2021). Org. Lett. 2021, 23, 7312–7312. DOI: 10.1021/acs.orglett.1c02829.
Ghiviriga, I. Selective Excitation 1D-NMR Experiments for the Assignment of the Absolute Configuration of Secondary Alcohols. J. Org. Chem. 2012, 77, 3978–3985. DOI: 10.1021/jo3003375.