Feng Tang
Assistant Professor
Research Focus
DNA integrity is constantly threatened by endogenous metabolites and environmental agents, producing a spectrum of DNA damage. If left unrepaired or mis-repaired, these lesions accumulate and result in permanent mutations, fueling tumorigenesis, neurodegeneration, immune dysfunction, and accelerated aging. Our long-term research goal is to develop a platform for multidimensional profiling of DNA damage in the human genome. By integrating high-throughput sequencing, mass spectrometry, chemical biology, machine learning, and bioinformatics, we aim to capture chemical structure, abundance, location, and time-resolved dynamics of DNA damage and repair proteins. This platform will enhance research in cancer biology, environmental toxicology, and the evaluation of off-target genome editing.
Education and Training
2020–2024: Postdoc, University of California, Riverside
2014–2020: Ph.D. , Wuhan University
2010–2014: B.S. , Wuhan University
Selected Awards
K99/R00 NIH Pathway to Independence Award (2023–2028)
CASMS Young Investigator Award (2025)
UCR Postdoc Awards for Excellence (2024)
Selected Activities
Graduate admissions committee Member (responsible for the Analytical division), 2025
Early Career (Advisory) Board of Chemical Research in Toxicology, 2025–
Editorial Board Members, Health and Metabolism, 2024–
Selected Publications
Feng Tang , Yinan Wang, Ting Zhao, Jun Yuan, Andrew H. Kellum, Jr., and Yinsheng Wang, DNA Polymerase κ Participates in Early S-Phase DNA Replication in Human Cells, Proc. Natl. Acad. Sci., 2024, 121, e2405473121.
Feng Tang, Yinan Wang, Zi Gao, Shiyuan Guo, and Yinsheng Wang, Polymerase η Recruits DHX9 Helicase to Promote Replication across Guanine Quadruplex Structures, J. Am. Chem. Soc., 2022, 144, 31, 14016-14020.
Feng Tang, Jun Yuan, Bi-Feng Yuan, Yinsheng Wang, DNA-Protein Cross-Linking Sequencing for Genome-Wide Mapping of Thymidine Glycol, J. Am. Chem. Soc., 2022, 144, 1, 454-462.