Matthew Eddy
Associate Professor
Research Focus
Our group investigates the molecular mechanisms of G protein–coupled receptor (GPCR) signaling using biophysical and chemical biology approaches. We study how endogenous cellular membranes regulate signaling, focusing on receptor–lipid interactions and their effects on drug responses. A long-term goal is to develop small molecules that modulate receptor-lipid interactions to alter receptor activity. We also engineer and characterize protein–polymer conjugates to design biologics with improved stability and function. Together, these efforts bridge fundamental insights into cell signaling with translational applications in drug discovery and therapeutic development.
Education and Training
2013–2018: Postdoctoral Research Fellow, Laboratories of Professors Raymond Stevens and Kurt Wüthrich, The Scripps Research Institute, San Diego, CA, and the University of Southern California, Los Angeles, CA
2005–2012: Ph.D. Physical Chemistry, Massachusetts Institute of Technology (lab of Prof. Robert Griffin)
2000–2004: B.S. Oberlin College (lab of Manish Mehta)
Selected Awards
NSF CAREER (2024)
Oak Ridge National Labs Ralph E. Powe Junior Faculty Award (2020)
American Cancer Society Postdoctoral Fellowship (2014–2017)
National Institutes of Health NRSA Postdoctoral Fellowship (2014)
Selected Activities
Mentor, UF Fellows of Chemical Biology Student Organization
NIH study section reviewer for R35 MIRA proposals
Selected Publications
Petracco E, Ferré G, Kabelka I, Ballante F, Carlsson J, Mulry E, Ray AP, Collins J, Allais F, Eddy MT. Development of an in situ GPCR fragment molecule screening approach with HRMAS NMR. ACS Chemical Biology 2025, 20, 401-411.
Thakur N, Ray AP, Lyman E, Gao ZG, Jacobson KA, Eddy MT. Membrane Mimetic-Dependence of GPCR Energy Landscapes. Structure 2024, 32, 523-535.
Thakur N, Ray AP, Sharp L, Jin B, Duong A, Pour NG, Obeng S, Wijesekara AV, Gao Z-G, McCurdy CR, Jacobson KA, Lyman E, Eddy MT. Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition. Nature Communications 2023, 14, 794.